WASHINGTON - Only 11 human stem cell lines are available for research, far fewer than originally estimated, the director of the U.S. National Institutes of Health (NIH) reports.

The finding led to a call for lifting the restriction that U.S. President George W. Bush placed on stem cell research.

NIH director Elias Zerhouni, writing in Friday's edition of the journal Science, says his agency is giving a high priority to research using stem cells because of the potential for treatment of diseases such as diabetes and Parkin- son's. But Zerhouni's review of the status of work supported by the NIH also shows that initial reports of more than 70 stem cell lines eligible for research were optimistic.

Donald Kennedy, editor in chief of the journal, contends in an accompanying editorial that development of new cell lines for research is necessary. "It is plainly not sound policy to retain the current restrictions on work" with human embryonic stem cells, he said.

Stem cells form very early in an embryo's development. They can develop into numerous types of cells to form organs and other parts of the body. Researchers hope to use these cells to repair damaged organs and cure diseases.

But the work is controversial because the cells are taken from days-old embryos, which then die.

Sources of cells are excess embryos from fertility clinics. The American Society for Assisted Reproductive Technology reported Thursday that there are 396,526 frozen embryos in storage in the United States and that 88 per cent are planned for use in helping families have children in the future.

The president has ordered that stem cell research can continue but scientists receiving federal funds can use only cell lines that were available on Aug. 9, 2001. The Health and Human Services Department reported at the time that more than 70 cell lines -- continuously propagating cell colonies -- were available.

But Zerhouni says in his paper that many of those cell lines were in the early stages of development and were not to the point where they could be distributed for use.

To overcome this, he reports, the NIH provided grants to bring the cell lines to the point where they can be used.

"As a consequence of this support, the number of cell lines available for widespread distribution has grown from a single cell line in the spring of 2002 to 11 cell lines at present," Zerhouni wrote.

Kennedy contends that new lines are needed for research because all current ones were developed in the presence of mouse cells that provided needed growth factors, and thus may be contaminated with viruses or proteins from those cells.

Human embryonic stem cells can now be grown without the mouse cells, Kennedy says, thanks to new methods.