From Roberta Friedman, PhD, ALSA Research Department Information Coordinator

A workshop funded by The ALS Association (ALSA) convened those who manipulate stem cells and those who investigate repair of nerve cells in a unique push towards effective stem cell therapy for amyotrophic lateral sclerosis (ALS, also called Lou Gehrig’s disease). Discussions at Banbury Center, Cold Spring Harbor Laboratory on Long Island in New York centered on both the basic biology of stem cells, and why the nervous system falters when trying to fix itself.

Generously funded by the Greater New York Chapter of The ALS Association, the sessions gave a forum for ALSA to encourage fresh collaborations. By bringing together different disciplines and introducing so many noted experts to the challenge of ALS, the workshop brought into focus the reality that “all the different aspects of replenishing motor neurons need to be carefully understood for design of a successful therapy,” said Lucie Bruijn, Ph.D., ALSA science director and an organizer of the meeting.

Spirited exchanges centered on the role of other cells in the nervous system and whether the supportive astrocytes might be as good or even better means to a therapeutic effect. Stem cells can be guided to produce astrocytes as well as or instead of neurons, so knowing how to steer stem cells is key. Bold new strategies will undoubtedly now be brought to bear on ALS. Stem cells do hold out hope and discussions included the prospect of a clinical trial of one proposed stem cell based therapy for ALS. Many hurdles must first be passed including testing in large animals to assure safety.